Principal Scientist (Scientific Director Level)- Nonclinical Drug Safety Job at Merck, South San Francisco, CA

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  • Merck
  • South San Francisco, CA

Job Description

Merck seeks a Principal Scientist to lead nonclinical drug safety strategy for discovery programs across immunology, oncology, and other therapeutic areas. The role involves risk assessment, program de-risking, and cross-functional collaboration from target identification through First-In-Human enabling studies.

Responsibilities

  • Represent nonclinical drug safety on discovery teams and governance committee reviews
  • Identify and assess risks associated with therapeutic targets using literature and internal data
  • Define and oversee nonclinical safety strategy for programs in all modalities
  • Lead early development teams and inform preclinical studies supporting product development
  • Collaborate with nonclinical staff across sites to execute appropriate studies

Requirements

  • PhD, DVM, MD, or equivalent degree in relevant field
  • Minimum 8+ years pharmaceutical industry experience in nonclinical safety assessment or toxicology
  • Demonstrated success navigating cross-functional matrix organizations and driving team decisions
  • Strong interpersonal and communication skills with ability to work across organizational levels
  • Experience with biopharmaceutical and small molecule drug development preferred
  • Knowledge of regulatory submissions and responses preferred

Compensation: $176,200.00 - $277,300.00 base

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